Getting there is half the battle: recent advances in delivering therapeutics.

TitleGetting there is half the battle: recent advances in delivering therapeutics.
Publication TypeJournal Article
Year of Publication2016
AuthorsSC Lesher-Perez, T Segura, and C Moraes
JournalIntegrative Biology : Quantitative Biosciences From Nano to Macro
Volume8
Issue1
Start Page8
Pagination8 - 11
Date Published01/2016
Abstract

Delivery of therapeutic molecules at the right time, place and at the correct dosage is critical to improve the effectiveness of therapeutic regimens. Barriers in the body, normally needed to maintain function, often impede delivery of therapeutic payloads to their target areas. Designing innovative solutions to circumvent these environmental factors, and ensure the timely delivery of therapeutic doses, is an essential element in improving human health. Here we highlight recent studies that focus on bypassing different barriers crucial for improving therapeutic delivery, by temporarily modifying the in vivo microenvironment, re-designing therapeutic carrier vehicles to improve control characteristics and on-demand delivery, and developing convenience-based strategies to improve patient compliance and access to therapeutics.

DOI10.1039/c5ib90052b
Short TitleIntegrative Biology : Quantitative Biosciences From Nano to Macro