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Metal-enhanced bioluminescence presents a great opportunity to achieve ultrasensitive analysis and imaging with low bioluminescent background and enhanced luminescence. We hereby report metal-enhanced bioluminescence based on bioluminescent protein nanocapsules conjugated with gold nanocrystals. Such gold-nanocapsule complexes exhibit near 10-fold enhancement in bioluminescent intensity and are effectively delivered into the cells with outstanding stability. This work offers a class of bioluminescent nanoparticles for imaging and other applications.

Juanjuan Du, Jing Jin, Yang Liu, Jie Li, Talar Tokatlian, Zuhong Lu, Tatiana Segura, Xu-bo Yuan, Xianjin Yang, Yunfeng Lu

Du J, Jin J, Liu Y, Li J, Tokatlian T, Lu Z, Segura T, Yuan X-B, Yang X, Lu Y