In situ forming injectable hydrogels for drug delivery and wound repair.

TitleIn situ forming injectable hydrogels for drug delivery and wound repair.
Publication TypeJournal Article
Year of Publication2018
AuthorsR Dimatteo, NJ Darling, and T Segura
JournalAdvanced Drug Delivery Reviews
Volume127
Start Page167
Pagination167 - 184
Date Published03/2018
Abstract

Hydrogels have been utilized in regenerative applications for many decades because of their biocompatibility and similarity in structure to the native extracellular matrix. Initially, these materials were formed outside of the patient and implanted using invasive surgical techniques. However, advances in synthetic chemistry and materials science have now provided researchers with a library of techniques whereby hydrogel formation can occur in situ upon delivery through standard needles. This provides an avenue to minimally invasively deliver therapeutic payloads, fill complex tissue defects, and induce the regeneration of damaged portions of the body. In this review, we highlight these injectable therapeutic hydrogel biomaterials in the context of drug delivery and tissue regeneration for skin wound repair.

DOI10.1016/j.addr.2018.03.007
Short TitleAdvanced Drug Delivery Reviews