vascular system

Therapeutic Angiogenic Materials

The 2017 American Heart Association statistics show that cardiovascular disease is the leading cause of death worldwide. In the US, a person dies of cardiovascular disease every 40 seconds. Insufficient blood supply, leading to severe organ and tissue failure, is a hallmark of cardiovascular disease; for example, coronary artery disease, peripheral arterial disease, and cerebrovascular disease lead to deficient blood supply to the heart, limbs, and brain, respectively. Approaches to restore blood supply to afflicted organs and tissues is currently being investigated to treat various aspects of cardiovascular disease.

The Segura Laboratory investigates local revascularization strategies in areas where insufficient blood flow has caused tissue damage and cavity formation, as in the case of stroke or diabetic foot ulcers. Our primary technologies are injectable hydrogel materials that can be applied to the site of injury using minimally invasive approaches.  The hydrogel materials are designed to promote revascularization and also encourage endogenous tissue repair. 

Our materials could be used for many other applications where a pro-regenerative blood supply is needed. If interested in exploring a collaboration, please contact Prof. Segura (tatiana.segura@duke.edu).